Survival in patients with Parkinson's disease: a ten-year follow
Por um escritor misterioso
Descrição
Background A thorough understanding of the factors that influence patient survival in Parkinson’s disease (PD) will aid in prognosis prediction and provide a new direction for disease modification treatment. Currently, there are no standardized mortality ratio (SMR) data for PD patients in the northern Chinese mainland. The main focus of this study was to determine which factors in the prospectively collected baseline characteristics can affect the survival of PD patients. In addition, for the first time, we investigated the SMR of PD patients in northern China. Methods Between 2009 and 2012, 218 PD patients were continuously recruited from the movement disorder clinic of the First Affiliated Hospital of Dalian Medical University and followed up until death or May 31, 2021. The prespecified prognostic variables were demographics, clinical features, lifestyle factors, and drug dose prospectively collected at baseline. To determine the independent predictors of survival during follow-up, the Cox proportional hazards model was used. Kaplan–Meier analysis was applied to estimate the overall survival curve and to compare survival between layers based on statistically significant predictors. The SMR of this northern Chinese mainland PD cohort was calculated. Results After a mean follow-up of 9.58 ± 2.27 years, 50 patients (22.90%) died. Factors that could individually predict shortened survival during follow-up included older age at onset (hazard ratio [HR] 1.10, 95% confidence interval [CI] 1.06–1.15), Hoehn and Yahr (H&Y) stage ≥ 3 (HR 9.36, 95% CI 2.82–31.03) and severe cognitive impairment (HR 6.18, 95% CI 2.75–13.88). Univariate Cox regression revealed that a certain amount of physical activity was associated with better survival (HR 0.41, 95% CI 0.22–0.74), while fatigue was associated with an increased risk of death (HR 2.54, 95% CI 1.37–4.70). The overall SMR was 1.32 (95% CI 0.98–1.74). Conclusions Older age at onset, higher baseline H&Y stage, and severe cognitive impairment have a negative impact on survival. The 10-year survival of PD patients is not significantly different from that of the general population in China.
The elephant in the room: critical reflections on mortality rates among individuals with Parkinson's disease
Serum Neurofilament Dynamics Predicts Cognitive Progression in de novo Parkinson's Disease - IOS Press
Breast cancer survival rate sees a 66% improvement over 20 years
Third-party bone marrow–derived mesenchymal stromal cell infusion before liver transplantation: A randomized controlled trial - American Journal of Transplantation
Current Clinical Applications of In Vivo Gene Therapy with AAVs: Molecular Therapy
Frontiers Neuroinflammation in Parkinson's Disease – Putative Pathomechanisms and Targets for Disease-Modification
Glycolysis-enhancing α1-adrenergic antagonists modify cognitive symptoms related to Parkinson's disease
Living With Parkinson's Disease: 3 Success Stories
Parkinson's disease - The Lancet
de
por adulto (o preço varia de acordo com o tamanho do grupo)
