Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Descrição
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
Dissociation of functional and structural plasticity of dendritic
Molecular mechanism of FMRP mediated regulation of local protein
FMRP and the Pathophysiology of Fragile X Syndrome - ScienceDirect
Molecular mechanisms behind mRNA localization in axons
Dual Regulation of Fragile X Mental Retardation Protein by Group I
IJMS, Free Full-Text
Excess Translation of Epigenetic Regulators Contributes to Fragile
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis
Frontiers Local mRNA translation and cytoskeletal reorganization
Local Protein Synthesis and Spine Morphogenesis: Fragile X
Frontiers Homeostatic Roles of the Proteostasis Network in Dendrites
Depletion of the Fragile X Mental Retardation Protein in Embryonic
Which Comes First in Fragile X Syndrome, Dendritic Spine
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