Temozolomide (NSC 362856), DNA Alkylator
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Descrição
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.
Temozolomide
Nanomaterials, Free Full-Text
Temozolomide 85622-93-1 wiki
Temozolomide Supplier, CAS 85622-93-1
Novel strategies of Raman imaging for monitoring the therapeutic benefit of temozolomide in glioblastoma - ScienceDirect
Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy - ScienceDirect
Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide
Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
Current and future developments in the use of temozolomide for the treatment of brain tumours - The Lancet Oncology
Frontiers An overview of glioblastoma multiforme and temozolomide resistance: can LC-MS-based proteomics reveal the fundamental mechanism of temozolomide resistance?
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