Frequency-specific neuromodulation of local and distant
Por um escritor misterioso
Descrição
A growing literature has focused on the brain’s ability to augment processing in local regions by recruiting distant communities of neurons in response to neural decline or insult. In particular, both younger and older adult populations recruit bilateral prefrontal cortex (PFC) as a means of compensating for increasing neural effort to maintain successful cognitive function. However, it remains unclear how local changes in neural activity affect the recruitment of this adaptive mechanism. To address this problem, we combined graph theoretical measures from functional MRI (fMRI) with diffusion weighted imaging (DWI) and repetitive transcranial magnetic stimulation (rTMS) in order to resolve a central hypothesis: how do aged brains flexibly adapt to local changes in cortical activity? Specifically, we applied neuromodulation to increase or decrease local activity in a cortical region supporting successful memory encoding (left dorsolateral prefrontal cortex or DLPFC) using 5Hz or 1Hz rTMS, respectively. We then assessed a region’s local within-module degree (WMD), or the distributed between-module degree (BMD) between distant cortical communities. We predicted that (1) local stimulation-related deficits may be counteracted by boosting BMD between bilateral PFC, and that this effect should be (2) positively correlated with structural connectivity. Both predictions were confirmed; 5Hz rTMS increased local success-related activity and local increases in PFC connectivity, while 1Hz rTMS decreases local activity and triggered a more distributed pattern of bilateral PFC connectivity to compensate for this local inhibitory effect. These results provide an integrated, causal explanation for the network interactions associated with successful memory encoding in older adults.
Insights Into the Effects of Low-Level Vagus Nerve Stimulation on
Subject-specific whole-brain parcellations of nodes and boundaries
Insights and opportunities for deep brain stimulation as a brain
Current Issue Table of Contents: Brain Stimulation: Basic
Frequency-specific neuromodulation of local and distant
Noninvasive theta-burst stimulation of the human striatum enhances
Temporal dynamics and frequency-specificity of distant phase
Frontiers Ultrasonic Neuromodulation and Sonogenetics: A New Era
Functional changes in prefrontal cortex following frequency
Neuro-stack as a programmable closed-loop neuromodulation system a
Modelling transcranial ultrasound neuromodulation: an energy-based
de
por adulto (o preço varia de acordo com o tamanho do grupo)